Seminarium z udziałem prof. Francesco Malatesty na Wydziale Biotechnologii
W ramach programu „Inicjatywa Doskonałości – Uczelnia Badawcza”, Wydział Biotechnologii Uniwersytetu Wrocławskiego zaprasza na seminarium, które poprowadzi profesor Francesco Malatesta z Sapienza University of Rome, Department of Biochemical Sciences (Rzym, Włochy). Wykład pt. „Ligand binding to HmuY-heme and mechanism of heme release” odbędzie się 7 października (wtorek) o godz. 10:45 w sali 1.05 na Wydziale Biotechnologii przy ul. F. Joliot-Curie 14A.
Biogram
Professor Francesco Malatesta is a distinguished scientist whose career is marked by numerous notable achievements in the field of biochemistry. His research has focused extensively on cytochrome c oxidase and other respiratory chain proteins, resulting in over one hundred publications in prestigious international journals. He developed a novel equation for analyzing second-order reactions, which has proved highly useful for studying electron transfer and protein folding. His work also includes the characterization of terminal oxidases from various bacterial species as well as structural and functional studies on enzymes with potential pharmaceutical applications, such as trypanothione reductase and pyridoxine 5′-phosphate oxidase. Another of his significant accomplishments is the cloning of the phosphodiesterase V gene from bovine lung, relevant to research on sildenafil.
Since 1994, Professor Malatesta has served as Full Professor of Biological Chemistry at prestigious Italian universities. He has been the coordinator of the Chemistry and Biochemical Propaedeutics course at Sapienza University of Rome since 2009, and since 2012 he has also coordinated the Biochemistry course in the English Medicine and Surgery Master’s Degree programme at the same institution. Between 2011 and 2016, he coordinated the PhD Course in Biochemistry at Sapienza, and since 2018 he has acted as an Education Ambassador within the FEBS Education and Training Committee, of which he became a full member in 2023.
His achievements further include co-authoring textbooks on medical chemistry and biochemistry, as well as numerous research papers published in leading journals such as PNAS, Journal of Biological Chemistry, FEBS Journal and Biochimica et Biophysica Acta. He has organized international conferences and courses on protein structure and function, and serves as editor and reviewer for several international biochemistry journals. Professor Malatesta is also the recipient of numerous research grants and an active member of prestigious scientific societies, including the Italian Society of Biochemistry and Molecular Biology and the American Society of Biochemistry and Molecular Biology.
Abstrakt
In this seminar, we present an extensive spectroscopic and kinetic characterization of the binding of exogenous gaseous ligands (CN⁻ and CO) to Porphyromonas gingivalis hemophore-like HmuY protein in complex with heme to elucidate the mechanistic basis of heme release. Our data support a model in which heme release from HmuY-heme is a multistep process, initiated by the rupture of one of the two coordination bonds between the heme iron and endogenous histidine residues.
Reference: J. Inorg. Biochem. 269 (2025) 112879).
Data publikacji: 10.09.2025
Dodane przez: M.K.
