pl. Uniwersytecki
Zainteresowania
- biochemistry molecular biology
- growth factor
- fgfr1
- receptor
- galectins
- cancer
- signaling
- glycosylation
- receptor clustering
- cytotoxic conjugates
Dyscyplina naukowa
- nauki biologiczne
Najnowsze publikacje
- Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins.
- Cross-talk between fibroblast growth factor receptors and other cell surface proteins.
- Intrinsically fluorescent oligomeric cytotoxic conjugates toxic for FGFR1-overproducing cancers.
- FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization.
- Targeting cellular trafficking of fibroblast growth factor receptors as a strategy for selective cancer treatment.
- Galectins as modulators of receptor tyrosine kinases signaling in health and disease
- Receptor clustering by a precise set of extracellular galectins initiates FGFR signaling
- The Significance of Cell Surface N-Glycosylation for Internalization and Potency of Cytotoxic Conjugates Targeting Receptor Tyrosine Kinases
- Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling
- The diverse dependence of galectin-1 and -8 on multivalency for the modulation of FGFR1 endocytosis
- The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells.
- Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1.
- Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors.
- FGF1 fusions with the Fc fragment of IgG1 for the assembly of GFPpolygons-mediated multivalent complexes recognizing FGFRs.
- Preparation of site-specific cytotoxic protein conjugates via maleimide-thiol chemistry and sortase A-mediated ligation.
